Apixaban Level Determination

Calibrators and controls now available

Apixaban (Eliquis®) is a direct Factor Xa-Inhibitor. Apixaban inhibits, as Rivaroxaban, directly, selectively and reversibly both free and in prothrombinase complex bound Factor Xa. The advantages of this substance are found in the oral dispensing form and the well predictable pharmacokinetics and anticoagulation. According to the manufacturer dose regulation and routine monitoring is consequently unnecessary.

 

However, in case of compliance control respectively by overdoses a quantitative activity determination may be necessary. That requires a suitable routine and automated test application.

 

Now CE-marked calibration- and control plasmas are available that with COAMATIC® Heparin, a widely distributed and in praxis since many years reliable anti-Factor Xa-method makes the determination of Apixaban possible.

 

Test package

Chromogenic method for anti-Factor Xa-determinationCOAMATIC® Heparin1 Kit41708

Calibration plasma Apixaban

For calibration by determination of Apixaban with chromogenic anti-Factor Xa-methods.

CAL Set

0 to ~500 ng/ml

5x1ml5090269

Control plasma Apixaban

For quality control by determination of Apixaban with chromogenic anti-Factor Xa-methods.

Control plasmas

in 2 different concentrations (~120 and 300 ng/ml).

low5x1ml5090271
high5x1ml5090270

 

Literature

Arznei-Telegramm: a-t 2011; 42: 59-60

 

System of Haemostasis

The Flash file 
shows the system 
of haemostasis