Dabigatran Level Determination

Test, calibrators and controls now available

Dabigatran (Pradaxa®) is a direct thrombin inhibitor. It is the active component of the oral anticoagulant prodrug Dabigatran Etexilate.

Dabigatran Etexilate is a low-molecular-weight prodrug that exhibits no pharmacological activity. Dabigatran Etexilate is rapidly resorbed after oral application and, via esterase-catalyzed hydrolysis in plasma and in the liver, converted to its active form Dabigatran. Dabigatran is a highly effective, competitive, reversible and direct thrombin inhibitor. The inhibition of thrombin prevents the thrombus formation, as thrombin causes the conversion of fibrinogen to fibrin in the coagulation cascade. Furthermore, Dabigatran inhibits both free and fibrin bound thrombin as well as the thrombin induced platelet aggregation.

In case of compliance, testing or suspicion of over dosage a quantitative activity determination might be necessary. That requires a suitable routine and automated test system. 

There is now with TECHNOCLOT® DTI a diluted thrombin time test available that by using suitable calibrators and controls allows reliable level determination of Dabigatran. 

 

Test package

Diluted thrombin time test for determination of direct thrombin inhibitorsTECHNOCLOT® DTI1 Kit5100025

Calibration plasma Dabigatran

For calibration by determination of Dabigatran with TECHNOCLOT® DTI       

CAL Set

50 to ~500 ng/ml

4 x 1 ml                                    5090210

Control plasma Dabigatran

For quality control by determination of Dabigatran with TECHNOCLOT® DTI 

Control plasmas
in 2 different concentrations (~130 and 300 ng/ml).

low5 x 1 ml5090214
high5 x 1 ml5090212

System of Haemostasis

The Flash file 
shows the system 
of haemostasis