Reagents for the Multiple Electrode Aggregometry (Impedance aggregometry)


The Multiple Electrode Aggregometry (MEA) is a method for measuring the platelet function in whole blood [1,2] where the electrical resistance, the impedance is measured between two electrodes.

After addition of different inducers, the platelets adhere to the electrodes in the blood sample during the measurement. The impedance between the electrodes during the adherence and aggregation of the platelets is measured and graphically shown [3]. The results are expressed in so-called aggregation units (AU) [4].


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  1. Ranucci, Marco; Simioni, Paolo (20 January 2016). Point-of-Care Tests for Severe Hemorrhage: A Manual for Diagnosis and Treatment. Springer. pp. 40–42. ISBN 978-3-319-24795-3
  2. Marcucci, Carlo; Schoettker, Patrick (17 September 2014). Perioperative Hemostasis: Coagulation for Anesthesiologists. Springer. pp. 54–56. ISBN 978-3-642-55004-1.3.
  3. Tóth O., Calatzis A., Penz S., Losonczy H, Siess W.: Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood; Thromb Haemost 2006; 96: 781-8
  4. CLSI. Platelet Function Testing by Aggregometry; Approved Guideline. CLSI document H58-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2008.
  5. Dacie & Lewis, ‘Practical Haematology’, Lewis, S.M., Bain, B.J. and Bates, I. (Editors); 9th Edition, Elsevier Science Ltd., 2002, pages 380-385.