Coagulation proteins

Coagulation proteins from human plasma

ArticleCharacteristicsQuantityArticle no.
Prothrombin (Factor II)Produced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.100 UHP 1002
1000 UHP 1002-1
Prothrombin Fragment 11 mgF1
Prothrombin Fragment 21 mgF2
α-Thrombin (Factor IIa)Produced from purified prothrombin by activation with factor Xa, factor Va and phospholipids. Lyophilized.1000 UHT 1002a
5000 UHT 1002a-5
Gamma-ThrombinA coagulatory non-active form of thrombin that retains much of its platelet activating capacity. Produced from α-thrombin by controlled proteolysis on trypsin-sepharose. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.1.0 mgHGT
Factor VII (Proconvertin)Produced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.0.1 mgHFVII 1007
1.0 mgHFVII 1007-1
Factor VIIaProduced from purified factor VII by activation with factor XIIa. Lyophilized.0.1 mgHFVIIa
1.0 mgHFVIIa-1
Factor IX (Christmas Factor)Produced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.100 UHFIX 1009
500 UHFIX 1009-5
Factor IXaβProduced from purified factor IX by activation with bovine factor XIa. Lyophilized.100 UHFIXa 1080
500 UHFIXa 1080-5
Factor XProduced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.100 UHFX 1010
500 UHFX 1010-5
Factor XaProduced from purified factor X by activation with RVV. Lyophilized.100 UHFXa 1011
500 UHFXa 1011-5
Factor XaβProduced from purified factor X by activation with RVV. Lyophilized.100 UHFXab
Factor XIProduced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.0.1 mgHFXI 1111
1.0 mgHFXI 1111-1
Factor XIaProduced from purified factor XI by activation with human factor XIIa. Lyophilized.0.1 mgHFXIa 1111a
1.0 mgHFXIa 1111a-1
Factor XIIProduced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.0.5 mgHFXII 1212
1.0 mgHFXII 1212-1
αFactor XIIaProduced by auto activation by purified factor XII with dextran sulfate. Contains < 5% βFactor XIIa. Lyophilized.0.5 mgHFXII 1212a
1.0 mgHFXII 1212a-1
PrekallikreinProduced from fresh frozen plasma. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.1.0 mgHPK 1302
5.0 mgHPK 1302-5
Prekallikrein PoolPrekallikrein Pool from human plasma. Lyophilized.2 mlHD49070
6 x 2 mlHD49071
KallikreinProduced by activation from prekallikrein with αFactor XIIa. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.1.0 mgHPKa 1303
5.0 mgHPKa 1303-5
Single chain HMW-KininogenContains > 95% single chain HMWK, specific coagulatory activity approx. 14 U/mg. Lyophilized.1.0 mgHK 1300
5.0 mgHK 1300-5
Two chain HMW-KininogenKinin-free two chain form of kininogen. Lyophilized.1.0 mg2HK 1301
5.0 mg2HK 1301-5
Factor XIIIZymogen of factor XIII (a2b2). Lyophilized.0.25 mgHFXIII 1313
Factor XIIIaProduced from human factor XIII by the action of human α-Thrombin. Thrombin is removed by chromatography.0.25 mgHFXIIIa 1314
FibrinogenPlasminogen-free1 gFIB 1
Plasminogen- and vWF-free1 gFIB 2
Plasminogen-, vWF- and Fibronectin-free1 gFIB 3
Peak '1'-Fibrinogen (Plasminogen-, FXIII- and Fibronectin-free)50 mgFIB-P1
Peak '2'-Fibrinogen50 mgP2FIB
CNBr fragments. Produced from human fibrinogen. Active as a t-PA-stimulator. Lyophilized.1 mgTC41104
5 mgTC41105
VitronectinProduced from a human plasma pool. Purity is proven with SDS-PAGE. Lyophilized.0.05 mgTC41140
FibronectinProduced from a human plasma pool. Purity is proven with SDS-PAGE. Lyophilized.1 mgTC41150
Protein ZProduced from human plasma.0.1 mgHPZ
Protein CProduced from fresh frozen plasma by a combination of salt precipitation and column chromatography. Lyophilized.0.1 mgHPC 1001
1.0 mgHPC 1001-1
Activated Protein C (APC)Produced from purified Protein C by activation with purified thrombin. Lyophilized.0.1 mgAPC
1.0 mgAPC-1
Protein SFree Protein S produced from plasma. Lyophilized.1.0 mgHPS
GPIIb/IIIaProduced from purified platelets. Lyophilized.1.0 mgGP2b3a
Heparin Cofactor IIProduced from fresh frozen plasma. Lyophilized.0.5 mgHCII
1.0 mgHCII-1
PlasminogenFor all determinations (e.g. streptokinase, t-PA, PAI and soluble fibrin), which require purified plasminogen. 95% Glu-plasminogen, Lyophilized, 1.5 mg, specific activity approx. 20 CU/mg (CU = casein units).1.5 mg81 06 63
Lys-PlasminogenProduced from a human plasma pool. Lys-plasminogen >90%, Glu-plasminogen <10%. Lyophilized.1 mgTC41014
5 mgTC41015
Glu-PlasminogenProduced froma human plasma pool. Homogeneity and purity are proven with SDS-PAGE. No detectable plasmin activity (by utilization of the chromogenic substrate S-2251). Lyophilized.1 mgTC41004
5 mgTC41005
PlasminProduced from homogenous Glu-plasminogen by urokinase. The complete activation is shown with the chromogenic substrate S-2251.1 mgHPLAS
Plasmin-Inhibitor (α2-Antiplasmin)Produced from human plasma by immuno-affinity- and ion-exchange chromatography.0.1 mgA2AP
u-PA (Urokinase)Purified protein, lyophilized.0.125 mgTC42000
scu-PA (single chain Urokinase)Purified protein, frozen.1 mgTC41054
Platelet factor 4 (PF4)Produced from human platelets by affinity chromatography and gel filtration.0.1 mgPF4
0.5 mgPF4-5
TAFI (Procarboxy-peptidase B)Produced from human plasma by immuno-affinity- and ion-exchange chromatography.0.1 mgTAFI
0.5 mgTAFI-5
Apolipoprotein H (β2GPI) 0.1 mgβ2GP-1
0.5 mgβ2GP-1-5
Complement factorsComplement component C1q1.0 mgHC1q
Complement component C1r1.0 mgHC1r
Complement component C1s1.0 mgHC1s
AntithrombinReagent for determination of heparin. Lyophilized, 10 IU. Please note: Reagent should not be used as standard (can contain more than 10 IU)1 x 10 IU82 07 20

Recombinant human coagulation proteins 

ArticleCharacteristicsQuantityArticle no.
PAI-1Lyophilized in 50 mM sodium acetate, 100 mM sodium chloride, 60 mM L-arginin-monohydrochloride and 0.01% Tween 80500 UTC41067
t-PALyophilized in 0.1 M potassiumphosphate buffer, 3.5 mg/ml L-arginin and 0.001 polysorbate Tween 80. Activty > 400 000 U/mg100 μgTC41072

Coagulation proteins from bovine plasma

ArticleCharacteristicsQuantityArticle no.
Prothrombin (Factor II)Produced from fresh bovine plasma. Homogeneity and purity are shown with SDS-PAGE. Lyophilized.100 UBP 1004
1000 UBP 1004-B
Thrombin (Factor IIa)Produced from bovine prothrombin by activation with prothrombinase complex. Activation enzymes are removed by column chromatography. A complete activation is shown with SDS-PAGE.1000 UBT 1002a
Factor V/VaProduced from fresh bovine plasma.100 UBFV/Va
AntithrombinProduced from fresh bovine plasma. Lyophilized.1.0 mgBAT
5.0 mgBAT-5
Factor IXProduced from fresh bovine plasma. Lyophilized.100 UBFIX 1005
500 UBFIX 1005-5
Factor IXaαProduced from purified factor IX by activation with RVV. Lyophilized.100 UBFIXa 1070
500 UBFIXa 1070-5
Factor IXaβProduced aus purified Factor IX by activation with factor XIa. Lyophilized.100 UBFIXa 1080
500 UBFIXa 1080-5
Factor XProduced from fresh bovine plasma. Purity is shown with SDS-PAGE. Lyophilized.100 UBFX 1006
Factor XaFor all determinations (e.g. heparin and antithrombin) that require purified factor Xa. Lyophilized, 71 nkat (determined with S-2222).1 x 71 nkat82 09 85
Factor XIaProduced from fresh bovine plasma by salt-precipitation and surface activiation. Lyophilized.100 UBFXIa-11a
FibrinogenProduced from fresh bovine plasma. Purity > 95% shown with SDS-PAGE. Coagulability > 95%. Lyophilized.1.0 gBFIB 1
5.0 gBFIB 1-5
Protein CProduced from fresh bovine plasma. Lyophilized.0.1 mgBPC 1003
1.0 mgBPC 1003-1
Activated Protein C (APC)Produced from Protein C by activation with thrombin. Lyophilized.0.1 mgBPCa
1.0 mgBPCa-1
PlasminogenProduced from fresh bovine plasma. Purity shown with SDS-PAGE. No detectable plasmin activity (by utilization of the chromogenic substrate S-2251). Lyophilized.1 mgBPg
Plasmin 1 mgBPLAS

Coagulation proteins from canine plasma

ArticleCharacteristicsQuantityArticle no.
FibrinogenProduced from fresh frozen plasma from dog by a combination of salt precipitation and column chromatography. Homogeneity and purity are proven with SDS-PAGE. Coagulability > 90%. Lyophilized.1 mgCFib
ThrombinProduced from canine prothrombin by ecarin activation. The venom is removed after activation.0.1 mgCIIa
Factor IXProduced from canine plasma and purified with ion-exchange chromatography.0.1 mgCFIX
Factor XProduced from canine plasma by a combination of salt precipitation and column chromatography. Lyophilized.0.1 mgCFX
Factor XaProduced from canine factor X by activation with Russell's Viper Venom. The venom is removed after activation. A complete activation is confirmed with SDS-PAGE.0.1 mgCFXa

Coagulation proteins from murine plasma 

ArticleCharacteristicsQuantityArticle no.
FibrinogenProduced from murine plasma by a combination of salt precipitation and column chromatography. Homogeneity and purity are proven with SDS-PAGE. Coagulability > 90%. Lyophilized.1 mgMFg
AntithrombinProduced from murine plasma. Purity > 94% shown with SDS-PAGE.0.1 mgMAT
ThrombinProduced from murine prothrombin by ecarin activation. The venom is removed after activation. A complete activation is proven with SDS-PAGE.0.05 mgMIIa
Factor XIIIProduced from murine plasma. Purity > 94% shown with SDS-PAGE.0.1 mgMFXIII
PlasminogenProduced from murine plasma. Purity > 94% shown with SDS-PAGE.1 mgMPg

Coagulation proteins from porcine plasma

ArticleCharacteristicsQuantityArticle no.
FibrinogenProduced from porcine plasma by a combination of salt precipitation and column chromatography. Homogeneity and purity are proven with SDS-PAGE. Coagulability > 90%. Lyophilized.1 mgPFib
ThrombinProduced from porcine prothrombin by activation with bovine factor Xa, factor Va and phospholipids. Activating enzymes are removed afterwards.0.1 mgPIIa
Factor XaProduced from porcine factor X by activation with Russell's Viper Venom. The venom is removed after activation. A complete activation is confirmed with SDS-PAGE.0.1 mgPFXa

Coagulation proteins from rabbit plasma

ArticleCharacteristicsQuantityArticle no.
FibrinogenProduced from rabbit plasma by a combination of salt precipitation and column chromatography. Purity > 94% shown with SDS-PAGE. Coagulability > 90%. Lyophilized.1 mgRbFg
ThrombinProduced from rabbit plasma. Purity > 90% shown with SDS-PAGE.0.1 mgRbIIa
Factor XProduced from rabbit plasma by a combination of salt precipitation and column chromatography. Purity > 94% shown with SDS-PAGE. Lyophilized.0.1 mgRbX
Factor XaProduced from rabbit factor X by activation with Russell's Viper Venom. The venom is removed after activation. A complete activation is confirmed with SDS-PAGE.0.1 mgRbXa

Coagulation proteins from rat plasma

ArticleCharacteristicsQuantityArticle no.
FibrinogenProduced from rat plasma by a combination of salt precipitation and column chromatography. Purity shown with SDS-PAGE. Coagulability > 90%. Lyophilized.1 mgRFib
ThrombinProduced from rat prothrombin by ecarin activation. The venom is removed after activation. Purity > 90% is proven with SDS-PAGE.0.1 mgRIIa
Factor XaProduced from rat factor X by activation with Russell's Viper Venom. The venom is removed after activation. A complete activation is confirmed with SDS-PAGE.0.1 mgRFXa

Inactivated human proteins

ArticleCharacteristicsQuantityArticle no.
Thrombin, inactivatedProduced from human α-thrombin, inactivated with an irreversible inhibitor.1 mgHTi
Factor VIIa, inactivatedProduced from human FVIIa, inactivated with chloromethyl ketone.0.1 mgHFVIIai
Factor IXaβ, inactivatedProduced from human factor IXaβ, inactivated with chloromethyl ketone.100 UHFIXai
Factor Xa, inactivatedProduced from human factor Xa, inactivated with GGACK.100 UHFXai
Activated Prot. C, inactivatedProduced from human activated protein C, inactivated with PPACK.0.1 mgAPCi

Des-Gla-proteins

ArticleCharacteristicsQuantityArticle no.
Des-Gla Factor II, humanHuman prothrombin with removed Gla-domain.10 mgHP-GD
Des-Gla Factor II, bovineBovine prothrombin with removed Gla-domain.1 mgBP-GD
Des-Gla Factor VIIa, humanProduced from purified human factor VIIa by processing with cathepsin G. Cathepsin G is removed after the reaction by chromatography.0.1 mgHFVIIaGD
Des-Gla Factor X, humanProduced from purified human factor X by processing with α-chymotrypsin. α-chymotrypsin is removed after the reaction with ion-exchange.1 mgHFX-GD
Des-Gla Factor Xaβ, humanProduced from purified human Des-gla factor X by activation with Russell's Viper Venom. The venom is removed after activation by gel filtration. A complete activation is shown with SDS-PAGE.1 mgHFXab-GD
Des-Gla Protein C, humanProduced from purified human protein C by processing with cathepsin G. Cathepsin G is removed after the reaction with chromatography.0.1 mgHPC-GD
Des-Gla Activated Protein C, humanProduced from purified human activated protein C by processing with cathepsin G. Cathepsin G is removed after the reaction with chromatography.0.1 mgAPC-GD

Protein activators and inhibitors

ArticleCharacteristicsQuantityArticle no.
Russell's Viper Venom (RVV)Produced from the venom of Russell's Viper. Purity is shown with SDS-PAGE. Activates factor X to factor Xa (human and bovine) as well as factor IX to factor IXaα. Lyophilized.0.1 mgRVV-X
1.0 mgRVV-X-1
Corn Trypsin InhibitorProduced from fresh corn. Homogeneity and purity are proven with SDS-PAGE. Lyophilized.1.0 mgCTI
Prekallikrein Activator 2 mlPKA
ProtacHighly purified extract of the venom from Agkistrodon Contortrix.5 x 1 ml5346212