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Thrombin Generation - Coagulation diagnostics of the future
TGA fully automated with the Ceveron - as simple as a routine assay
The first despriptions of thrombin generation (TG) were published as early as 1986. TG in the classical meaning, should be understood as the formation of the thrombin curve after addition of a slow reacting thrombin specific substrate. While routine parameters as Quick and aPTT measure only a part of the coagulation cascade (approx. 2% of the formed thrombin), the TG as global parameter includes the total thrombin formation process. TG provides additional information. From the course of the curve, conclusions can be drawn about tendencies of haemophilia or thrombophilia as well of the effects of anticoagulants.
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Literature
- Kalz J, ten Cate H, Spronk H. Thrombin generation and atherosclerosis. J Thromb Thrombolysis. Jan 37(1), 45-55, 2014
- Stief TW, Fröhlich S, Renz H. Determination of the global fibrinolytic state. Blood Coagul Fibrinolysis18, 479–487, 2007.
- Agnelli G, Becattini C. New anticoagulants. Semin Thromb Hemost 32, 793–802, 2006.
