SARS CoV-2 & COVID-19
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV 2), is the virus that causes Corona Virus Disease 2019 (COVID-19). The SARS-CoV-2 is a single-stranded RNA coronavirus and causes respiratory infections. Coronaviruses consist of spike protein, hemagglutinin esterase dimer, a membrane glycoprotein, an envelope protein, a nucleo-capsid and RNA. Results suggest that the spike protein retains sufficient affinity for the angiotensin converting enzyme 2 (ACE2) receptor to be used as a mechanism for cell entry. The transmission of coronaviruses by humans is primarily caused by close contact via respiratory droplets such as sneezing or coughing. IgG is the most common immunoglobulin that is produced in response to an antigen. It is retained in the body for a long-term response after initial exposure. The COVID-19 diagnosis includes SARS-CoV-2 detection by PCR. However, serological tests can be useful to determine if patients have been exposed to the virus.
Ning Tang Huan Bai Jiale Gong Ziyong Sun Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy doi.org/10.1111/jth.1481
Bikdeli B, Madhavan MV, Jimenez D, Chuich T, Dreyfus I, Driggin E, Nigoghossian CD, Ageno W, Madjid M, Guo Y, Tang LV, Hu Y, Giri J, Cushman M, Quéré I, Dimakakos EP, Gibson CM, Lippi G, Favaloro EJ, Fareed J, Caprini JA, Tafur AJ, Burton JR, Francese DP, Wang EY, Falanga A, McLintock C, Hunt BJ, Spyropoulos AC, Barnes GD, Eikelboom JW, Weinberg I, Schulman S, Carrier M, Piazza G, Beckman JA, Steg PG, Stone GW, Rosenkranz S, Goldhaber SZ, Parikh SA, Monreal M, Krumholz HM, Konstantinides SV, COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up. doi.org/10.1016/j.jacc.2020.04.031
Christophe Gris, Isabelle Quéré, Antonia Pérez-Martin, Jean-Yves Lefrant, Albert Sotto. Uncertainties on the prognostic value of D-dimers in COVID-19 patients. onlinelibrary.wiley.com/doi/epdf/10.1111/jth.14876