Reagents for the Multiple Electrode Aggregometry

Multi-electrode aggregometry (MEA) is a method for determining platelet function in whole blood [1,2]. The electrical resistance, the impedance, is measured between two electrodes.

After adding various inductors, platelets are deposited on electrodes immersed in the blood sample during the measurement. The impedance between the electrodes during the deposition and aggregation of the platelets is measured and graphically recorded [3]. The results are expressed in so-called aggregation units (AU) [4].
The test can be used to monitor anti-aggregation therapy and to determine platelet function. [5]

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Literatur

1. Ranucci, Marco; Simioni, Paolo (20 January 2016). Point-of-Care Tests for Severe Hemorrhage: A Manual for Diagnosis and Treatment. Springer. pp. 40–42. ISBN 978-3-319-24795-3
2. Marcucci, Carlo; Schoettker, Patrick (17 September 2014). Perioperative Hemostasis: Coagulation for Anesthesiologists. Springer. pp. 54–56. ISBN 978-3-642-55004-1.3.
3. Tóth O., Calatzis A., Penz S., Losonczy H, Siess W.: Multiple electrode aggregometry: A new device to measure platelet aggregation in whole blood; Thromb Haemost 2006; 96: 781-8
4. CLSI. Platelet Function Testing by Aggregometry; Approved Guideline. CLSI document H58-A. Wayne, PA: Clinical and Laboratory Standards Institute; 2008.
5. Dacie & Lewis, ‘Practical Haematology’, Lewis, S.M., Bain, B.J. and Bates, I. (Editors); 9th Edition, Elsevier Science Ltd., 2002, pages 380-385.