Synonym Fitzgerald factor
Molecular weight 122.000 Da
Half-life 144 hours
Plasma-concentration 74 - 84 μg/ml
Normal range 70 - 130 %

High molecular weight kininogen (HMWK or Fitzgerald factor) is a cofactor for the activation of prekallikrein, factor XII and factor XI. HMWK has its own enzyme activity.

HMWK has a multi-domain structure and numerous functions, inhibition of cystein proteases of the type of papain, participation in inflammatory processes and increase of the vessel permeability. By the cleavage of HMWK by kallikrein bradykinin is released. This causes an improvement of the microcirculation by vasodilatation.

Clinical significance

The rare hereditary HMWK-deficiency is seen from an extremely prolonged aPTT. Risk of bleeding or thrombosis is, however, not present.


Suspected hereditary HMWK-deficiency, unexplained prolongation of the aPTT.


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TC Fitzgerald Trait Plasma

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