Danaparoid-Natrium (Orgaran®)


Molecular mass 6.000 Da
Bioavailability 100% after subcutaneous injection
Peak concentration 4-5 after drug administration
Half-life 25 hours

Danaparoid Sodium (Orgaran®) is an anticoagulant drug from the group of heparinoids preventing coagulation similar to heparin. It enhances the inhibitory activity of antithrombin. It consists of a mixture of glycosaminoglycans, derived from animal intestinal mucosa.

Clinical significance

Danaparoid Sodium (Orgaran®) is used as an alternative anticoagulant drug for patients that cannot be treated with heparins e.g. due to a heparin induced thrombocytopenia (HIT) type II. Correlation of anti-factor Xa activity and administered dose of Orgaran is linear. 


If monitoring of anticoagulation therapy or an individual dose setting is necessary, a functional anti-factor Xa chromogenic assay (e.g. Coamatic® Heparin) should be used. In this assay, plasma spiked with Orgaran® has to be used for generation of a standard curve.


  • Prevention of deep vein thrombosis in situations, where heparin should not be applied, including patients with heparin-induced thrombocytopenia (HIT) type II
  • Treatment of thromboembolic disorders in patients who require urgent parenteral anticoagulation because of the development or history of heparin-induced thrombocytopenia (HIT) type II


  1. Fachinformation Orgaran® der Aspen Pharma Trading Ltd. Stand Juli 2014
  2. Schuster B. Monitoring of anticoagulants. Hämostaseologie 29, 268-273, 2009
  3. Alban S. Pharmakologie der Heparine und direkten Antikoagulanzien Hämostaeologie 28: 400-420, 2008.
Test kits
Chromogenic assay



Calibration plasma

Calibration plasma Orgaran®


Control plasma

Control plasma Orgaran®


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