Danaparoid-Natrium (Orgaran®)
Biochemistry
| Molecular mass | 6.000 Da |
| Bioavailability | 100% after subcutaneous injection |
| Peak concentration | 4-5 after drug administration |
| Half-life | 25 hours |
Danaparoid Sodium (Orgaran®) is an anticoagulant drug from the group of heparinoids preventing coagulation similar to heparin. It enhances the inhibitory activity of antithrombin. It consists of a mixture of glycosaminoglycans, derived from animal intestinal mucosa.
Clinical significance
Danaparoid Sodium (Orgaran®) is used as an alternative anticoagulant drug for patients that cannot be treated with heparins e.g. due to a heparin induced thrombocytopenia (HIT) type II. Correlation of anti-factor Xa activity and administered dose of Orgaran is linear.
If monitoring of anticoagulation therapy or an individual dose setting is necessary, a functional anti-factor Xa chromogenic assay (e.g. Coamatic® Heparin) should be used. In this assay, plasma spiked with Orgaran® has to be used for generation of a standard curve.
Indication
- Prevention of deep vein thrombosis in situations, where heparin should not be applied, including patients with heparin-induced thrombocytopenia (HIT) type II
- Treatment of thromboembolic disorders in patients who require urgent parenteral anticoagulation because of the development or history of heparin-induced thrombocytopenia (HIT) type II