|Molecular mass||53.000 Da|
|Plasma concentration||1 - 1.3 g/l|
|Normal range||Activity: 100%|
The inhibitor is mainly responsible for the inhibition of the activity of PMN-elastase in plasma. About 90% of the elastase in plasma is inhibited by α1-antitrypsin. Although it also inhibits various other serine proteases, as e.g. thrombin, factor XIa, trypsin and activated protein C (APC), α1-antitrypsin is of no significance in the coagulation system.
Reduced concentrations are observed in patients with sepsis or multi-organ failure as well as in some genetic lung and liver diseases. As an acute phase protein, increased concentrations of α1-antitrypsin can be determined is some situations. Inherited deficiency may cause liver disease and lung emphysema at an early age.
- Control of sepsis and multi-organ failure
- Monitoring of the elastase-inhibiting potential
- Screening of newborns for α1-antitrypsin deficiency
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