News
Apixaban Level Determination
Calibrators and controls now available
Apixaban (Eliquis®) is a direct Factor Xa-Inhibitor. Apixaban inhibits, as Rivaroxaban, directly, selectively and reversibly both free and in prothrombinase complex bound Factor Xa. The advantages of this substance are found in the oral dispensing form and the well predictable pharmacokinetics and anticoagulation. According to the manufacturer dose regulation and routine monitoring is consequently unnecessary.
However, in case of compliance control respectively by overdoses a quantitative activity determination may be necessary. That requires a suitable routine and automated test application.
Now CE-marked calibration- and control plasmas are available that with COAMATIC® Heparin, a widely distributed and in praxis since many years reliable anti-Factor Xa-method makes the determination of Apixaban possible.
Test package
| Chromogenic method for anti-Factor Xa-determination | COAMATIC® Heparin | 1 Kit | 41708 |
Calibration plasma Apixaban
For calibration by determination of Apixaban with chromogenic anti-Factor Xa-methods. | CAL Set 0 to ~500 ng/ml | 5x1ml | 5090269 |
Control plasma Apixaban
| For quality control by determination of Apixaban with chromogenic anti-Factor Xa-methods. | Control plasmas in 2 different concentrations (~120 and 300 ng/ml). | low | 5x1ml | 5090271 |
| high | 5x1ml | 5090270 |
Literature
Arznei-Telegramm: a-t 2011; 42: 59-60