Rapid assay for the determination of ADAMTS-13 activity

Semiquantitative results of ADAMTS-13 activity within 30 minutes

Thrombotic-thrombocytopenic purpura (TPP) is a life-threatening disease that needs a fast diagnosis and initiation of adequate therapeutic regime. If ADAMTS-13 activity is below 10%, together with an appropriate clinical setting this is highly indicative of TTP. 

Determination of ADAMTS-13 activity can also be useful from the differential diagnostic point of view: the hemolytic-uremic syndrome shows similarly but typically involves normal or only mildly reduced ADAMTS-13 activity. 

TECHNOSCREEN® ADAMTS-13 Activity is a semiquantitative flow through assay for the determination of ADAMTS-13 activity levels in human citrated plasma. This assay is intended as a screening tool for estimating ADAMTS-13 activity.

Weblinks:

https://www.youtube.com/watch?v=JjSJEyyxrX8

https://www.youtube.com/watch?v=YITuGY6aSDU

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Literature

1. Rogers HJ, Annen C, Lichtin AE. "Thrombotic thrombocytopenic purpura: The role of ADAMTS 13". Cleve Clin J Med. 2016 Aug.; 83(8): 597-603
2. Vacca VM Jr. "Acquired autoimmune thrombotic thrombocytopenic purpura". Nursing 2019 Jan; 49(1): 22-29
3. Coppo P. "Management of thrombotic thrombocytopenic purpura". Transfus Clin Biol. 2017 Sep.; 24(3): 148-153
4. Di Pasquale I, Budde U, Tona F, Bertomoro A, Lombardi AM, Famoso G, Bertozzi I, Dittmer R, Schneppenheim S, Fabris F. "Link between von Willebrand factor multimers, relapses and coronory microcirculation in patients with thrombotic thromcocytopenic purpura in remission". Thrombo Res. 2019 Jan.; 173: 42-47